CRISPR Handcuffs: Anti-CRISPR protein AcrIIA6, shown as handcuffs, sequesters and inhibits two Cas9 molecules (red), while a naturally resistant variant (green) is able to cleave its target DNA.
Handcuffs for CRISPR – my new drawing for a Molecular Cell paper!
You may not see it, but an evolutionary battle is being waged all around us between bacteria and the viruses that target them. This drawing depicts an exciting new discovery…